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KMID : 0811720010050000175
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Korean Journal of Physiology & Pharmacology
2001 Volume.5 No. 0 p.175 ~ p.0
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Behavioral Signs of Pain in a Rat Spinal Cord Contusion Model
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Jung Ji-In
Hong Seung-Kil
Yoon Young-Wook
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Abstract
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Painful sensations are frequent and troublesome sequelae of paraplegia or quadriplegia associated with traumatic spinal cord injury. It is reported that approximately two-thirds of spinal cord injured patients experience pain with nearly one-third having severe pain. Patients with chronic pain following spinal cord injury generally fail to respond to conventional treatments and have a compromised quality of life. However, lack of appropriate animal models with clinical relevance prevents us exploring the mechanisms of chronic pain and managing them properly. The aim of this study was to demonstrate behavioral signs of pain in spinal cord contused rats. Spinal cord injury was produced by dropping a 10-g weight from 6.25 or 12.5 mm onto the exposed cord at the level of T13 using the New York University impactor in male Sprague-Dawley rats under anesthesia. Rats having same surgical procedures without actual weight drop were served as control group. Behavioral tests were performed to determine the presence of mechanical allodynia and cold allodynia and assess the degree of motor paralysis for several weeks after spinal cord contusion. After spinal cord contusion, the behavioral signs of mechanical and cold allodynia were significantly increased on the both side of hind paw as compared to the preoperative state in especially 6.25 mm drop group. In 12.5 mm drop group, some of rats showed increased sensitivity to innocuous mechanical and cold stimuli, but changes were not significant compared to the preoperative state as a group. Control rats did not show any significant changes. These results suggest that mechanical and cold allodynia are present in spinal contusion model, which is a widely used experimental model and could be used as pain model. The milder spinal cord injury produces more behavioral signs of pain in contusion injury.
Source: Korean J Physiol Pharmacol.2001 Dec;5(Suppl II):S98
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